Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterols
نویسندگان
چکیده
منابع مشابه
Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels.
ABCG5 and ABCG8 transporters play an important role in the absorption and excretion of sterols. Missence polymorphisms (Gln604Glu in the ABCG5 and Asp19His, Tyr54Cys, Thr400Lys, and Ala632Val in the ABCG8) in these genes have been described. In 131 males and 154 females whose dietary composition markedly changed and lipid parameters decreased over an 8-year follow-up study (total cholesterol de...
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Journal of Lipid Research Volume 56, 2015 487 Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. The last decade has seen extraordinary advances in our understanding of intestinal lipid metabolism, driven at least in part through attempts to mitigate the ongoing epidemic of obesity and metabolic disease ( 1 ). For example, weight loss strategies including gast...
متن کاملLocalization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine
BACKGROUND The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in the rare autosomal recessive disease, Sitosterolemia (MIM 210250). Mutations in either, but not both, of two genes ABCG5 or ABCG8, comprising the STSL locus, are now known to caus...
متن کاملThematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes. The REP-like protein Rab GDP dissociation inhibit...
متن کاملCoexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.
Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking. To determine the site of action of ABCG5 and ABCG8, we expressed recombinant, epitope-tagged mouse ABCG5 and ABCG8 in cultured cells. Both ABCG5 and ABCG8 underwent N-linked glycosylation. When either protein was expressed individually in cells, the N-linked su...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2018
ISSN: 0022-2275
DOI: 10.1194/jlr.r084244